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Nontobacco Nicotine in Orthopaedic Surgery: Current Knowledge and Limitations of Database Investigations.

Farlow M, Burks WG, Holbrook H, Bravo C · JBJS reviews, 2026

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Researchers examined how non-tobacco nicotine products like e-cigarettes and nicotine pouches affect bone and surgical healing. While laboratory studies suggest nicotine may interfere with healing, real-world evidence in patients is unclear due to poor data quality and inability to distinguish between traditional smokers and exclusive nicotine product users.

Relevance to India: None stated.