Metabolite-driven epigenetic modifications remodel immune cell functions in COPD: From Lactylation to Succinylation.
This review examines how cellular metabolic changes trigger epigenetic modifications that alter immune cell behavior in COPD patients. The authors propose that COPD involves a persistent 'inflammatory memory' driven by metabolic dysfunction and oxidative stress, even after smoking stops, and suggest targeting these metabolic-epigenetic pathways could offer new treatments.
Relevance to India: None stated.
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