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Combination bupropion-zonisamide facilitates rapid reduction in smoke exposure and prevents weight gain during switching to electronic nicotine delivery systems: A randomized clinical trial.

Rose JE, Behm FM, Willette PN, Botts TL, Botts DR · Drug and alcohol dependence, 2026

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A medication combination of bupropion and zonisamide helped people who smoke cigarettes switch to e-cigarettes more successfully than either drug alone or placebo, with faster initial reductions in smoking and weight loss instead of weight gain.

Relevance to India: None stated.